Description:NebuSelect™ Recombinant Biotinylated Human Notch 2, Avi-His-tag(Cat#NBL-242233) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Leu26-Gln530.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 57 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.

Target Name:Notch 2SynonymsAGS2; Notch-2; NOTCH2; N2ECD; HJCYS; N2

Target Information:Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch-2 is lethal, showing that not all functions overlap.Notch-2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

Amino Acid Sequence: Leu26-Gln530

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)