Description:NebuSelect™ Recombinant Human SEMA4B, His-tag(Cat#NBL-242130) is expressed in HEK293 with His tag at the C-Terminus.It contains Leu44-Glu717.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 75.8 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.

Target Name:SEMA4BSynonymsSemaphorin-4B; Semaphorin-C; SEMA4B; KIAA1745; SEMAC; MGC131831; SemC

Target Information:Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.

Amino Acid Sequence: Leu44-Glu717

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)