Description:NebuSelect™ Recombinant Human SIRP alpha V8, Avi-His-tag(Cat#NBL-242054) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Glu31-Arg369(S44L, S50T, I52T, H54R, V57A).

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 40.1 kDa. Due to glycosylation, the protein migrates to 52-68 kDa based on Bis-Tris PAGE result.

Target Name:SIRP alpha V8SynonymsCD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3

Target Information:Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction.

Amino Acid Sequence: Glu31-Arg369(S44L, S50T, I52T, H54R, V57A)

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)