Description:NebuSelect™ Recombinant Mouse TMEM106B, hFc-tag(Cat#NBL-242045) is expressed in HEK293 with hFc tag at the C-Terminus.It contains Pro119-Gln275.

Species:Mouse

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 44.8 kDa. Due to glycosylation, the protein migrates to 65-68 kDa based on Bis-Tris PAGE result.

Target Name:TMEM106BSynonymsTransmembrane protein 106B；Tmem106b

Target Information:TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dysfunction (Klein et al, 2017).

Amino Acid Sequence: Pro119-Gln275

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)