Description:NebuSelect™ Recombinant Human Tim-3/HAVCR2, His-tag(Cat#NBL-242014) is expressed in HEK293 with His tag at the C-Terminus.It contains Ser22-Arg200.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 20.7 kDa, Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result.

Target Name:Tim-3/HAVCR2SynonymsCD366; TIM3; TIM-3; TIMD-3; TIM 3;-FLJ14428; HAVCR2; KIM3

Target Information:Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene.TIM3 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8 T-cell exhaustion. TIM3 has also been shown as a CD4 Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.

Amino Acid Sequence: Ser22-Arg200

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)