Description:NebuSelect™ Recombinant Human Thyroid Peroxidase, His-tag(Cat#NBL-241996) is expressed in HEK293 with His tag at the C-Terminus.It contains Phe19-Arg846.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 90.6 kDa. Due to glycosylation, the protein migrates to 95-105 kDa based on Bis-Tris PAGE result.

Target Name:Thyroid PeroxidaseSynonymsTPO; THPO; MGC163194; MGDF; MKCSF; ML; MPLLG; THCYT1; MGDFC-mpl ligand; MK-CSF; MPL ligand; Thrombopoietin; TPOMKCSF

Target Information:Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase that encodes a 933 amino-acid residue (aa) molecule with a single membrane-spanning region. Thyroid peroxidase plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues and the coupling of iodotyrosine residues in Tg, resulting in the formation of T3 and T4. It is a frequent epitope of autoantibodies in autoimmune thyroid disease, for example, the expression of thyroid peroxidase is lost in papillary thyroid carcinoma.

Amino Acid Sequence: Phe19-Arg846

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)