Description:NebuSelect™ Recombinant Cynomolgus TREM2, His-tag(Cat#NBL-241984) is expressed in HEK293 with His tag at the C-Terminus.It contains His19-Ser174.

Species:Cynomolgus

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 18.5 kDa. Due to glycosylation, the protein migrates to 33-42 kDa based on Bis-Tris PAGE result.

Target Name:TREM2SynonymsPLOSL2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c

Target Information:TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2- consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.

Amino Acid Sequence: His19-Ser174

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)