Description:NebuSelect™ Recombinant SARS-CoV-2 Spike RBD (Lambda C.37), His-tag(Cat#NBL-241699) is expressed in HEK293 with His tag at the C-Terminus.It contains Arg319-Phe541(L452Q, F490S).

Species:SARS-COV-2

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 26.15 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Bis-Tris PAGE result.

Target Name:Spike RBD (Lambda C.37)

Target Information:The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The resulting mouse-adapted strain at passage 6 (called MASCp6) showed increased infectivity in mouse lung and led to interstitial pneumonia and inflammatory responses in both young and aged mice after intranasal inoculation. Deep sequencing revealed a panel of adaptive mutations potentially associated with the increased virulence. In particular, the N501Y mutation is located at the receptor binding domain (RBD) of the spike protein.

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)