Description:NebuSelect™ Recombinant Canine CD40/TNFRSF5, His-tag(Cat#NBL-241414) is expressed in HEK293 with His tag at the C-Terminus.It contains Glu21-Ala194.

Species:Canine

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 20.14 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on Bis-Tris PAGE result.

Target Name:CD40/TNFRSF5

Target Information:CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells.

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)