Description:NebuSelect™ Recombinant Mouse Noggin(Cat#NBL-241374) is expressed in HEK293 without tag.It contains Gln28-Cys232.

Species:Mouse

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 23.07 kDa. Due to glycosylation, the protein migrates to 28-33 kDa based on Bis-Tris PAGE result.

Target Name:Noggin

Target Information:Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt.

Amino Acid Sequence: Gln28-Cys232

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)