Description:NebuSelect™ Recombinant Human SIGIRR, hFc-tag(Cat#NBL-241361) is expressed in HEK293 with hFc tag at the C-terminus.It contains Met1-His118.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 39.29 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.

Target Name:SIGIRR

Target Information:TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. Structurally, it is characterized by a single extracellular Ig domain, an intracellular TIR domain and 95-aa cytoplasmic tail. Recently, TIR8 was shown to inhibit NF-B activation by members of the IL-1/TLR family. The inhibitory activity of TIR8 was associated with trapping of TRAF6 and IRAK1.

Amino Acid Sequence: Met1-His118

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)