Description:NebuSelect™ Recombinant Human DKK1, hFc-tag(Cat#NBL-241306) is expressed in HEK293 with hFc tag at the C-terminus.It contains Thr32-His266.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 52.54 kDa. Due to glycosylation, the protein migrates to 65-80 kDa based on Bis-Tris PAGE result.

Target Name:DKK1

Target Information:Dickkopf related protein 1 (Dkk-1) is the founding member of the Dickkopf family of proteins that includes Dkk-1, -2, -3, -4, and a related protein, Soggy. Dkk proteins are secreted proteins that contain two conserved cysteine-rich domains separated by a linker region. Dkk antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation.

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)