Description:NebuSelect™ Recombinant Biotinylated Human EGFRVIII, Avi-His-tag(Cat#NBL-241031) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Leu25-Ser378.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 41.6 kDa. Due to glycosylation, the protein migrates to 60-78 kDa based on Bis-Tris PAGE result.

Target Name:EGFRVIIISynonymsErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ERBB; ERBB1; HER1; PIG61; NISBD2

Target Information:The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.

Amino Acid Sequence: Leu25-Ser378

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)