Description:NebuSelect™ Recombinant Human FGFR1 alpha (IIIc), Avi-His-tag(Cat#NBL-240869) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Arg22-Glu374.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 42 kDa. Due to glycosylation, the protein migrates to 68-83 kDa based on Bis-Tris PAGE result.

Target Name:FGFR1 alpha (IIIc)SynonymsFGF R1a; FGFR1 alpha

Target Information:Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding.FGFR1 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.

Amino Acid Sequence: Arg22-Glu374

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)