Description:NebuSelect™ Recombinant Cynomolgus LILRA4/CD85g, His-tag(Cat#NBL-240846) is expressed in HEK293 with His tag at the C-Terminus.It contains Glu24-Asn446.

Species:Cynomolgus

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 47.7 kDa. Due to glycosylation, the protein migrates to 58-68 kDa based on Bis-Tris PAGE result.

Target Name:LILRA4/CD85gSynonymsCD85g; ILT7; ILT-7; ILT7MGC129598; LILRA4; MGC129597

Target Information:LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain.LILRA4 function coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades.

Amino Acid Sequence: Glu24-Asn446

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)