Description:NebuSelect™ Recombinant Human EPHB2, His-tag(Cat#NBL-240710) is expressed in HEK293 with His tag at the C-Terminus.It contains Val19-Leu543.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 59.2 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Bis-Tris PAGE result.

Target Name:EPHB2SynonymsDRT; ERK; HEK5; TYRO5; CAPB; EK5; EPHT3; PCBC; Cek5; EphB2; EPHT3MGC87492; Nuk; Qek2; Sek3

Target Information:EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated pathologic characteristics of glioblastoma multiforme (GBM) such as invasion and migration. EPHB2 is epigenetically overexpressed in hypoxia, a condition highly prevalent in malignancy. Furthermore, HIF-2α is required for EPHB2 stabilization by hypoxia.

Amino Acid Sequence: Val19-Leu543

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)