Ensure Potency That Therapies Require Without the Toxicity Risk

The cutting-edge formulations of PRIME-XV FreezIS Cryopreservation Media Portfolio are optimized to protect and preserve cells without compromising functionality no matter how manufacturing needs change.DMSO-free, protein-free, animal component-free, chemically defined cryopreservation medium

Designed to maintain viability and maximize efficiency for preserving cells in today’s advanced applications.

• Eliminates the risk of DMSO toxicity and maintains potency of human mesenchymal stromal/stem cells (MSCs), PBMCs (T cells), and hematopoietic stem cells (HSCs) throughout cryopreservation
• Achieves high post-thaw viability and growth: Viability of thaw cell typically within 10% of freezing cell viability. (Viability assessed by Trypan Blue assay)
• Supports cell density for MSC and HSC from 0.5 X 106 cells/mL to 1 X 106 cells/mL and PBMCs (T cells) minimum 5 X 106 cells/mL
• Maintains cell surface marker expression of MSCs and PBMCs (T cells) post-thaw
• Preserves the physical integrity and functionality of cells post-thaw after storage for short-term at -80°C* and long-term storage in liquid nitrogen to -196°C
• Can directly replace DMSO- and/or serum-containing media with comparable post-thaw cell viability

Accelerate life-changing therapies to market: Now available as an excipient and non-excipient medium

The cutting-edge formulations of PRIME-XV FreezIS Cryopreservation Media Portfolio are optimized to protect and preserve cells without compromising functionality no matter how manufacturing needs change.

For tissue banks we recommend following the guidelines provided by each individual tissue bank and local regulations. Excipient (91140EX)** and non-excipient (91140)† products are available as complete, ready-to-use media.

Meet with our team of cell culture media experts to determine the right PRIME-XV formulation for manufacturing success.

*Human MSC and PBMC (T Cell) data available for short-term storage. Human HSC data is not available.

**Excipient products are for research or further manufacturing use only. Not for injection as a stand-alone product or diagnostic procedures. Product can be used as excipient, which means that the cells and media combined are treated as one product that is to be approved by the FDA. Testing for individual applications is the responsibility of the customer.​

†Non-excipient products are for research or further manufacturing use only. Not for injection or diagnostic procedures. Testing for individual applications is the responsibility of the customer.