Introduction
CaM-kinase II (CAMK2) is a prominent Ser/Thr protein kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Likely autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Expression of CAMK2 delta is significantly increased in patients suffering from dilated cardiomyopathy.
Specificity
Predicted Reactivity
Mouse, Pig, Rabbit
Other Names
CAMK2D; CAMKD; Calcium/calmodulin-dependent protein kinase type II subunit delta
NCBI Accession #
NP_001212.2;NP_742112.1;NP_742113.1;NP_742125.1;NP_742126.1;NP_742127.1
Other Accession #
O77708; Q95266; Q6PHZ2
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
56369
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | The anti-CAMK2delta C-term Pab (Cat# 102-17184) is used in Western blot to detect CAMK2 delta in serum-starved HeLa cell lysate. |
 | Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
 | Formalin-fixed and paraffin-embedded human brain tissue reacted with CAMK2 delta Antibody (C-term) (Cat# 102-17184), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.