Introduction
CNO6L plays a role in the deadenylation of mRNAs in the cytoplasm. CNO6L has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. CNO6L may be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. This protein involved in deadenylation-dependent degradation of CDKN1B mRNA.
Specificity
Predicted Reactivity
Mouse, Xenopus
Other Names
CNOT6L; CCR4B; CCR4-NOT transcription complex subunit 6-like; Carbon catabolite repressor protein 4 homolog B
NCBI Accession #
NP_653172.2
Other Accession #
Q8VEG6; Q5XH73; Q6IR85
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
63001
Recommended Dilutions
IHC: 1:50-100; WB: 1:1000
 | CNO6L Antibody (C-term) (Cat# 102-16434) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CNO6L Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
 | CNO6L Antibody (C-term) (Cat# 102-16434) western blot analysis in Sk-Br-3 cell line tissue lysates (35ug/lane).This demonstrates the CNO6L antibody detected the CNO6L protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.