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Anti-Cellular Apoptosis Susceptibility (C-term) Antibody
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Rabbit Anti-Cellular Apoptosis Susceptibility (C-term) Antibody, 400 ul
原料试剂 动物实验室研发实验室
价格
3841
品牌 瑞博奥/RayBio
地区 -
货号 102-14253
产地 进口
选择规格
400 µl
易享客服
RayBio多因子检测
瑞博奥(广州)生物科技股份有限公司
中国广东省广州市
营业执照已审核
RayBio是一家总部位于美国乔治亚州的生物技术公司,专注于开发和制造高质量的蛋白质检测工具以及提供相应的服务,聚焦于蛋白质组学的检测分析领域和多组学的应用,以严格的质量控制和创新的技术为基础。 Raybio具有可用于生命科学研究、疾病研究及疾病治疗相关药物、医学技术等功能探究的全线产品,包括国际领先、最多专利、最多指标的抗体芯片、流式多因子芯片等多因子检测试剂盒超700余种;单靶标检的ELISA试剂盒,可用于细胞因子含量、药物作用等检测;以及超过18,000种抗体、小分子产品,可用于WB、ELISA、IF等免疫学实验。 我们的产品和服务被全球的学术、政府和制药实验室广泛使用,用于疾病诊断、药物筛选和基础研究,已助力全球客户在Nature, Nature Medicine, Cell, Lancet, PNAS等世界顶级期刊上发表了数万篇文章。
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产品规格 图文详情 技术文档
产品规格
品牌名称
瑞博奥/RayBio
货号
102-14253
国产/进口
进口
规格
400 µl
图文详情

Introduction

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.

Specificity

Predicted Reactivity
Zebrafish, Bovine
Other Names
CSE1L; CAS; XPO2; Exportin-2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter
NCBI Accession #
NP_001243064.1;NP_001307.2
Other Accession #
Q9ERK4; Q7SZC2; A5D785

Format

Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
110417
Recommended Dilutions
WB: 1:1000
Western blot analysis of lysates from Hela, Jurkat, Ramos, mouse NIH/3T3 cell line (from left to right), using CSE1L Antibody (Cat# 102-14253). 102-14253 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
Western blot analysis of anti-CSE1L Pab (Cat# 102-14253) in, from left to right, A375, CEM, and mouse heart cell line lysates (35ug/lane). CSE1L(arrow) was detected using the purified Pab.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
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