Introduction
Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Specificity
Other Names
KSR2; Kinase suppressor of Ras 2
NCBI Accession #
NP_775869.3
Other Accession #
NP_775869.3
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
107632
Recommended Dilutions
IHC: 1:50-100; WB: 1:1000; FC: 1:10-50
 | KSR2 Antibody (C-term) (Cat# 102-11095)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KSR2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
 | KSR2 Antibody (C-term) (Cat# 102-11095) western blot analysis in 293,K562,HepG2,Hela cell line lysates (35ug/lane).This demonstrates the KSR2 antibody detected the KSR2 protein (arrow). |
 | KSR2 Antibody (C-term) (Cat# 102-11095) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.