Introduction
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
Specificity
Predicted Reactivity
Monkey
Other Names
CYP1A1; Cytochrome P450 1A1; CYPIA1; Cytochrome P450 form 6; Cytochrome P450-C; Cytochrome P450-P1
NCBI Accession #
NP_000490.1
Other Accession #
P33616; NP_000490
Format
Type
Mouse Monoclonal Antibody (Mab)
Calculated Molecular Weight (Da)
58165
Recommended Dilutions
WB: 1:100-1000
 | CYP1A1 Antibody (C-term) (Cat# 102-10388) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CYP1A1 antibody detected the CYP1A1 protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.