图文详情
Application:IF
Reactivity: Mouse,Rat (predicted: Human,Rabbit,Pig,Sheep,Cow,Dog)
APPD is a lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF). It is a representative of a novel family of PH and FYVE domain-containing proteins and induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway.
Cellular localization: Nucleus. Cytoplasm, perinuclear region. Lysosome. Note=Translocates to lysosome during apoptosis.