图文详情
Application:IF
Reactivity: Rat (predicted: Human,Mouse,Rabbit,Sheep,Cow,Dog,Horse)
E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked polyubiquitination of TMEM173/STING, thereby playing a key role in innate immunity. TMEM173/STING 'Lys-63'-linked ubiquitination activates the production of type I interferon IFN-beta following detection of pathogen- and host-derived double-stranded DNA.