Application:IF
Reactivity: Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Cow,Zebrafish,Chicken,Dog,Horse)
LARP1 is a 1,096 amino acid protein belonging to the LARP family. LARP1 contains two conserved regions, one that shares homology with La/SSB proteins and one that is conserved only across LARP family proteins. Within the La/SSB conserved region, LARP1 contains a HTH La-type RNA-binding domain, which may indicate a role in RNA stabalization and folding. Upon DNA damage, LARP1 is phosphorylated by ATR or ATM. LARP1 interacts with many signaling intermediate proteins, including 14-3-3. Widely expressed, LARP1 levels are highest in heart. LARP1 exists as three isoforms produced by alternative splicing.