Application:IF,ICC/IF
Reactivity: (predicted: Human,Mouse,Rat,Horse)
ZC3HDC3 is a 948 amino acid protein that contains five C3H1-type zinc finger domains. ZC3HDC3 plays a regulatory role in nuclear adenylation and export. Two isoforms of ZC3H13 exists as a result of alternative splicing events. The gene encoding ZC3H13 maps to chromosome 8, which encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects.