Application:IF
Reactivity: Human,Mouse (predicted: Rat,Cow)
The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. The Kelch repeat and BTB domain-containing protein 11 (KBTBD11) contains 1 BTB (POZ) domain and 4 Kelch repeats suggesting a role in transcription regulation. The gene encoding KBTBD11 maps to chromosome 8, which contains about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas.