Application:IF,ICC/IF
Reactivity: (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow)
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF239, also known as Zinc finger protein MOK-2 or HOK-2, is a 458 amino acid protein belonging to the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF239 contains nine C2H2-type zinc finger domains. Due to the presence of these domains, ZNF239 may be involved in transcriptional regulation. ZNF239 is present at high levels in brain, breast and testis, and has no expression in liver or placenta.