Application:IF
Reactivity: Mouse (predicted: Human,Rat,Pig,Sheep,Chicken,Dog,Horse)
The gene encodes a 246-amino acid polypeptide containing an RNA binding motif, a putative nuclear localization signal, and phosphorylation sites. The alpha subunits comprises the outer rings of the proteasome. Some alpha subunits contain a functional nuclear localization signal; proteasomes are found in both the nuclear and cytoplasmic compartments of the cell. Alpha subunits may constitute a physical barrier that limits access of cytosolic proteins into the inner proteolytic chamber.