Application:IF,ICC/IF
Reactivity: (predicted: Human,Mouse,Rat,Pig,Cow,Monkey)
Cytochrome c1 is a component of the ubiquinol-cytochrome c reductase complex, which is a respiratory chain that generates an electrochemical potential, coupled to ATP synthesis. Specifically, cytochrome c transfers electrons from the cytochrome bc1 complex to cytochrome c oxidase by transiently binding to the complex. The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1). Cytochrome c1 binds one heme per subunit as a result of a mutation-induced collapse of the di-heme cytochrome structure. The cytochrome c1 gene is thought to be regulated by E2F and Sp1 transcription factors.