Application:IF
Reactivity: Human
GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1) is a capillary endothelial cell protein that provides a platform for LPL-mediated processing of chylomicrons. Consisting of 184 amino acids, GPIHBP1 is a single-pass membrane protein that may be regulated by dietary factors and by PPARγ. Mutations in the gene encoding GPIHBP1 are linked to chylomicronemia syndrome, a rare genetic disorder caused by LPL deficiency and is characterized by enlarged liver and spleen, inflammation of the pancreas, fatty deposits under the skin and possibly deposits in the retina of the eye.