Application:IF
Reactivity: Human,Rat (predicted: Mouse,Pig)
Nuclear migration is essential for growth, development and cellular function of multicellular organisms. NUDCD3 (NudC domain containing 3) is a 361 amino acid protein that contains one CS domain and is phosphorylated upon DNA damage by either ATR or ATM. Ubiquitously expressed, NUDCD3 has been observed to colocalize with Golgi marker proteins during interphase of mitosis in HeLa cells, and is found at low levels in brain, ovary and heart. The gene encoding NUDCD3 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.