Application:IF
Reactivity: Mouse,Rat (predicted: Human,Pig,Cow,Dog)
TRIP1-TRIP15 genes encode thyroid hormone receptor β (TR β)-binding proteins. TRIP15, along with Cops2 and Alien comprise the second subunit (CSN2) of the COP9 signalosome (CSN), an eight-subunit complex with a variety of functions. CSN regulates Skp1-cullin-F-box protein (SCF) ubiquiting ligases by deconjugating Nedd8 from the Cul1 component of the SCF, and also associates with protein kinase activities targetting p53, c-Jun, and IκB. Consequently, inhibition of SCF ubiquitin ligase activity occurs, and cell cycle progression halts at the transition from G1 to S phase. TRIP15 contains an acidic region in the N terminus, a putative zinc finger in the C terminus, and a central hydrophobic core region flanked by 2 putative α-helical structures and a nuclear localization signal.