Application:IF,ICC/IF
Reactivity: Human,Rat (predicted: Mouse,Pig,Cow,Chicken,Dog,Horse)
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008].[FUNCTION] Acts as a transcriptional repressor.[SUBUNIT] Forms homodimers. Also forms heterodimers with ZHX1 and ZHX3. Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts with NFYA.[SUBCELLULAR LOCATION] Nucleus. [TISSUE SPECIFICITY] Ubiquitously expressed. [SIMILARITY] Belongs to the ZHX family.