图文详情
Application:IF,Flow-Cyt,ICC/IF
Reactivity: Human,Mouse,Rat,Cow (predicted: Rabbit,Pig,Chicken,Dog,Horse)
The transcription factor PITX3 is expressed selectively in the midbrain and regulates the differentiation and survival of dopaminergic neurons. Lack of this factor results in a degeneration similar to that seen in Parkinson's disease. PITX3 is also important in eye developement; mutations of the PITX3 gene have been associated with a familial form of cataracts.