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GM130 Rabbit pAb, HRP conjugated
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需招商
原料试剂 研发实验室
价格
￥2980.00
品牌 Bioss博奥森生物
地区 中国,北京,北京市
货号 bs-24915R-HRP
产地 国产
选择规格
100ul
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Bioss博奥森生物
北京博奥森生物技术有限公司
北京
博奥森：专注科研，以优质抗体引领未来
博奥森生物，自2001年诞生以来，始终坚守在生命科学前沿，为全球科研人员提供卓越品质的免疫学试剂产品与服务。我们拥有资深的科学家团队、先进的抗体发现、验证与生产平台，始终坚持“自主研发、原始创新”的理念，确保每一款产品都能达到国际标准，持续提供“4R” 品质科研工具【Repeatable（可重复）、Replicable（可复制）、Reproducible（可再现）和Reliable（可靠的）】。
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产品规格
图文详情
技术文档
产品规格
品牌名称
Bioss博奥森生物
货号
bs-24915R-HRP
国产/进口
国产
规格
100ul
储存条件
Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
使用范围
WB
货源
新品
图文详情
Application:WB
Reactivity: Human (predicted: Mouse,Rat)
The docking of transport vesicles to their target membrane is mediated by p115. GM130, a cis-Golgi matrix protein, interacts specifically with p115 and provides a membrane docking site. Both GM130 and p115 are involved in vesicle tethering to Golgi membranes. The amino-terminus of GM130 binds to p115, whereas the carboxy-terminus binds to Golgi membranes. Both Giantin and GM130 compete for binding to p115. Thus, p115-Giantin and p115-GM130 interactions might mediate independent membrane tethering events. Transport from the ER to the cis/medial Golgi compartments requires the action of p115, GM130 and Giantin via a sequential rather than a coordinate mechanism. Mitotic phosphorylation of GM130 at Serine 25 is mediated by Cdc2, prevents binding to p115 and is directly involved in mitotic Golgi fragmentation. GM130 is phosphorylated in prophase as the Golgi complex starts to break down, and remains phosphorylated in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble.
Reactivity: Human (predicted: Mouse,Rat)
The docking of transport vesicles to their target membrane is mediated by p115. GM130, a cis-Golgi matrix protein, interacts specifically with p115 and provides a membrane docking site. Both GM130 and p115 are involved in vesicle tethering to Golgi membranes. The amino-terminus of GM130 binds to p115, whereas the carboxy-terminus binds to Golgi membranes. Both Giantin and GM130 compete for binding to p115. Thus, p115-Giantin and p115-GM130 interactions might mediate independent membrane tethering events. Transport from the ER to the cis/medial Golgi compartments requires the action of p115, GM130 and Giantin via a sequential rather than a coordinate mechanism. Mitotic phosphorylation of GM130 at Serine 25 is mediated by Cdc2, prevents binding to p115 and is directly involved in mitotic Golgi fragmentation. GM130 is phosphorylated in prophase as the Golgi complex starts to break down, and remains phosphorylated in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble.
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