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Noggin Rabbit pAb, AP conjugated
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原料试剂 研发实验室
价格
￥2980.00
品牌 Bioss博奥森生物
地区 中国,北京,北京市
货号 bs-2975R-AP
产地 国产
选择规格
100ul
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Bioss博奥森生物
北京博奥森生物技术有限公司
北京
博奥森：专注科研，以优质抗体引领未来
博奥森生物，自2001年诞生以来，始终坚守在生命科学前沿，为全球科研人员提供卓越品质的免疫学试剂产品与服务。我们拥有资深的科学家团队、先进的抗体发现、验证与生产平台，始终坚持“自主研发、原始创新”的理念，确保每一款产品都能达到国际标准，持续提供“4R” 品质科研工具【Repeatable（可重复）、Replicable（可复制）、Reproducible（可再现）和Reliable（可靠的）】。
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产品规格
图文详情
技术文档
产品规格
品牌名称
Bioss博奥森生物
货号
bs-2975R-AP
国产/进口
国产
规格
100ul
储存条件
Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
使用范围
IHC-P,IHC-F
货源
新品
图文详情
Application:IHC-P,IHC-F
Reactivity: Human,Mouse,Rat (predicted: Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse)
Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.
Reactivity: Human,Mouse,Rat (predicted: Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse)
Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.
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