图文详情
Application:IF,Flow-Cyt
Reactivity: Human,Rat (predicted: Mouse,Rabbit,Pig,Cow,Dog,Horse)
APH1a is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the APH-1 family.