图文详情
Application:WB,IHC-P,IHC-F
Reactivity: Human,Mouse,Rat (predicted: Pig,Cow,Chicken)
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53 dependent and independent mechanisms.