Application:IF,Flow-Cyt
Reactivity: Human,Mouse,Rat (predicted: Rabbit,Pig,Sheep,Cow,Dog)
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]