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Z433927330 is a potent and selective aquaporin-7 (AQP7) inhibitor. Z433927330 is also a partial AQP3 inhibitor (IC50, ~0.7-0.9 μm) and a potent and efficacious inhibitor of mouse AQP7 water permeability (IC50, ~0.2 μm). Moreover, Z433927330 blocked aquaglyceroporin H2O2 permeability.