基本信息：
CAS：155751-72-7
分子式：C44H67KO13

分子量：843.09

MDL：MFCD00214356

纯度：≥90% (HPLC), powder

溶解性：溶于乙醇（5 ug/50 ul = 124.2 μM）

产品简介：
冈田酸 (Okadaic acid) 是一种海洋毒素，是蛋白质磷酸酶 (PP) 的抑制剂，包括 PP1 (IC50=15-50 nM)、PP2A (IC50=0.1-0.3 nM)、PP3 (IC50=3.7-4 nM)、PP4 (IC50=0.1 nM) 和 PP5 (IC50=3.5 nM)，其中对 PP2A 的亲和力最显著，但不抑制 PP2C。Okadaic acid 通过抑制 PP 增加了多种蛋白的磷酸化，并具有肿瘤启动子的作用。Okadaic acid 诱导 tau 蛋白磷酸化。
作用靶点：Phosphatase; Apoptosis;
作用通路：Metabolic Enzyme/Protease; Apoptosis

体外研究：
Okadaic acid (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3].
Okadaic acid (10 nM; 8 hours) increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[3]

体内研究：
Okadaic acid (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection[5]

REFERENCES：
[1]. Kleppe R, et al. Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action. Mar Drugs. 2015 Oct 22;13(10):6505-20.
[2]. Valdiglesias V, et al. Okadaic acid: more than a diarrheic toxin. Mar Drugs. 2013 Oct 31;11(11):4328-49.
[3]. del Campo M, et al. Okadaic acid toxin at sublethal dose produced cell proliferation in gastric and colon epithelial cell lines. Mar Drugs. 2013;11(12):4751-4760.
[4]. Cho MH, et al. Increased phosphorylation of dynamin-related protein 1 and mitochondrial fission in okadaic acid-treated neurons. Brain Res. 2012 May 15;1454:100-10.
[5]. Baker S, et al. A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions. Acta Neuropathol Commun. 2016;4:32.