图文详情
Application:WB,IHC-P,IHC-F,IF,ICC/IF,IP
Reactivity: Human
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP.Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling.May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.