图文详情
Application:WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,IP
Reactivity: Human,Mouse,Rat
Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines.Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation.