Application:WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,IP
Reactivity: Human,Mouse,Rat
Required for pre-mRNA splicing as component of the spliceosome.Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.