Application:WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,IP
Reactivity: Human (predicted: Mouse,Rat)
Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum.Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin.In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF.