图文详情
Application:WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,IP
Reactivity: Human,Mouse,Rat
Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection.