产品类型

重组兔单抗

英文名称

GPX4 Recombinant Rabbit mAb

中文名称

谷胱甘肽过氧化酶4重组兔单抗

英文别名

GPX4; GSHPx-4; MCSP; mitochondrial; PHGPx; phospholipid hydroperoxidase; snGPx; snPHGPx; Sperm nucleus glutathione peroxidase.

产品应用

WB=1:500-2000, IHC-P=1:50-200, IHC-F=1:50-200, IF=1:50-200, ICC/IF=1:50-200 
 

Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

交叉反应

Human, Mouse, Rat

抗体来源

Rabbit

免疫原

A synthesized peptide derived from human GPX4: 18-65/197

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

12H13

理论分子量

22

检测分子量

17

储存液

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
 

研究领域

Cancer > Cancer Metabolism > Cellular metabolic process

Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers

Metabolism > Pathways and Processes > Redox metabolism > Antioxidants

Metabolism > Types of disease > Cancer

Signal Transduction > Metabolism > Mitochondrial

亚基

Monomer. Has a tendency to form higher mass oligomers.

亚细胞定位

Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm.

组织特异性

Present primarily in testis.

相似性

Belongs to the glutathione peroxidase family.

SWISS

P36969

Gene ID

2879

功能

Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.

保存条件

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 2879 Human

Entrez Gene : 625249 Mouse

Entrez Gene : 29328 Rat

Omim : 138322 Human

SwissProt : P36969 Human

SwissProt : O70325 Mouse

SwissProt : P36970 Rat

Unigene : 433951 Human

Unigene : 359573 Mouse

Unigene : 3647 Rat

背景资料

Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.

标记抗体

应用