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活动日期:2026.4.20-2026.5.31

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Species    
Human        

Protein Construction    
Noggin (Gln28-Cys232), Accession # Q13253

Tag    
No tag

Expression System    
HEK293

Purity    
> 95% as determined by SDS-PAGE

Predicted Molecular Mass   
23 kDa

SDS-PAGE   
28~33 kDa, under reducing conditions

Endotoxin   
<0.1 EU/μg of the protein by the LAL method.        

Biological Activity    
Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is <20ng/mL in the presence of 50 ng/mL of Recombinant Human BMP‑4.  

Formulation    
Lyophilized from a 0.22μm filtered solution in PBS
Reconstitution    
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder at 100 μg/mL in sterile deionized water  

Storage&Stability    
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.        
12 months from date of receipt, at lower than -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 °C under sterile conditions after reconstitution.

Usage    
Research use only

Background    
Noggin is a secreted homodimeric glycoprotein that functions primarily as an antagonist of bone morphogenetic proteins (BMPs). It regulates BMP activity by binding to specific BMPs—such as BMP4 with high affinity and BMP7 with lower affinity—thereby blocking their interaction with both type I and type II receptors. Structurally, Noggin contains an N-terminal acidic region, a central heparin-binding domain, and a C-terminal cysteine-knot motif. It is expressed in various adult tissues, including the central nervous system, lung, skeletal muscle, and skin. During development, Noggin plays critical roles in neural tube formation, joint morphogenesis, and chondrocyte regulation. Mutations in its cysteine-knot region are linked to skeletal dysplasias. In stem cell biology, Noggin is widely used to maintain pluripotency in human embryonic stem cells and to support neural stem cell maintenance or differentiation into dopaminergic neurons under specific culture conditions.