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活动日期:2026.4.20-2026.5.31

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Species    
Human        

Protein Construction    
FGF-2 (Ala135-Ser288), Accession # P09038-4      

Tag    
No tag

Expression System    
E. coli        

Purity    
> 95% as determined by SDS-PAGE

Predicted Molecular Mass   
17 kDa

SDS-PAGE   
17 kDa, under reducing conditions

Endotoxin    
<0.1 EU/μg of the protein by the LAL method.        

Biological Activity    
Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblasts. The ED50 for this effect is 0.13-1 ng/mL.          

Formulation    
Lyophilized from a 0.22μm filtered solution in PBS  

Reconstitution    
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder at 100 μg/mL in sterile deionized water  

Storage&Stability    
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.        
12 months from date of receipt, at lower than -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 °C under sterile conditions after reconstitution.

Usage    
Research use only

Background    
FGF-2 (fibroblast growth factor-2), also commonly known as bFGF (basic Fibroblast Growth Factor), is a member of the FGF family. It binds FGFRs and heparan sulfate and modulate the function of a wide range of cell types. Once the FGF2/FGFR/HSPG complex is formed, it triggers a cascade of signals inside the cell (primarily the MAPK/ERK and PI3K/AKT pathways), which ultimately lead to changes in gene expression and the cellular responses. FGF-2 is a pleiotropic molecule, meaning it has multiple, diverse effects depending on the context and type of cell it acts upon. Its main functions include: cell proliferation, angiogenesis, cell survival (anti-apoptosis), tissue repair and wound healing, embryonic Development and nervous system function.